Why are breakthrough infections with Omicron anything but a blessing and why will re-vaccination of C-19 vaccinees with an updated S(Omicron)-based C-19 vaccine make things even worse? | Geert Vanden Bossche 

I am herewith reacting to the scientifically simplistic and naïve conclusions drawn in some recent scientific publications: https://www.biorxiv.org/content/10.1101/2022.04.01.486695v1.full.pdf https://www.medrxiv.org/content/10.1101/2022.04.29.22274477v1.full.pdf

One has no choice but to react to these papers as their authors reach some dangerous but false conclusions such as:

However, vaccination increase neutralization capacity against these emerging variants and would likely offer good protection against severe disease” or:

In aggregate, our results suggest that despite possible imprinting of the immune response by previous vaccination, the preformed B-cell memory pool can be refocused and quantitatively remodeled by exposure to heterologous S proteins to allow neutralization of variants that evade a previously established neutralizing antibody response” or:

“…..our observations suggest that a vaccine adapted to the Omicron S protein could similarly reshape the B-cell memory repertoire and therefore may be more beneficial than an extended series of boosters with the existing Wuhan-Hu-1 spike based vaccines”

‍The question in the title of this article can be phrased more clearlyas follows:

Why do breakthrough infections with Omicron have a deleterious impact on both, individual and public health? Why will re-vaccination of C-19 vaccinees with an updated S(Omicron)-based C-19 vaccine during a pandemic make breakthrough infections even more likely and further increase population-level immune pressure on viral virulence?

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